Getting Secretory Granules Ready for Prime Time
نویسندگان
چکیده
Several rare human diseases have shed important light on the secretory pathway required for lymphocyte cytotoxicity. In this issue of Cell, Feldmann et al. identify mutations in Munc13-4 as a cause of familial hemophagocytic lymphohistiocytosis. Munc13-4 appears to be involved in the priming of cytotoxic granules prior to fusion with the plasma membrane.
منابع مشابه
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عنوان ژورنال:
- Cell
دوره 115 شماره
صفحات -
تاریخ انتشار 2003